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apalutamide will minimize the extent or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine which have been CYP3A4 substrates can lead to lessen exposure to those remedies.modafinil will boost the degree or influenc